Article
A PAb240+ conformation of wild type p53 binds DNA.
Oncogene - 19 Sept 1996
McLure K G, Lee P W
Abstract excerpt
It is generally accepted that wild type (growth suppressing) p53 is capable of binding to a consensus DNA sequence and is in a conformation recognizable by antibody PAb246 (for murine p53), but not by antibody PAb240. Conversely, mutant forms of p53 incapable of DNA binding often assume conformat...
Topics
- Animals
- Antibodies, Monoclonal
- Binding Sites
- Consensus Sequence
- DNA
- Epitopes
- Mice
- Phenotype
- Protein Binding
- Protein Conformation
- Rabbits
- Reticulocytes
- Tumor Suppressor Protein p53