Mapping of the interaction sites of the growth suppressor protein p53 with the regulatory beta-subunit of protein kinase CK2.

Article

Mapping of the interaction sites of the growth suppressor protein p53 with the regulatory beta-subunit of protein kinase CK2.

Oncogene - 16 Nov 1995

Appel K, Wagner P, Boldyreff B, Issinger O G, Montenarh M

Abstract excerpt

p53 plays an essential role in cellular growth control. Some of its distinct biological functions are regulated by interaction with cellular proteins. We have previously (Wagner et al., 1994) shown that p53 binds to the regulatory subunit of protein kinase CK2. Using C-terminal protein fragments...

Topics

Binding Sites
Casein Kinase II
Macromolecular Substances
Mutation
Peptide Fragments
Peptide Mapping
Phosphorylation
Protein Serine-Threonine Kinases
Recombinant Proteins
Tumor Suppressor Protein p53

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