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Article

Jun inhibits myogenic differentiation.

Oncogene - 1 Oct 1991

Su H Y, Bos T J, Monteclaro F S, Vogt P K

Abstract excerpt

Myoblasts from skeletal muscle of chicken or Japanese quail embryos were infected with avian sarcoma virus 17 (ASV-17), a retrovirus carrying the jun oncogene. At high multiplicities of infection ASV-17-induced morphologic transformation inhibited fusion of myoblasts into myotubes and stimulated extended replication. The expression of the muscle-specific proteins desmin, myosin and creatine phosphokinase was...

Topics

Animals
Avian Sarcoma Viruses
Cell Differentiation
Cell Transformation, Viral
Cells, Cultured
Chick Embryo
Coturnix
Genes, jun
Muscles
Mutation
Myofibrils
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1656361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1656361-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Jun inhibits myogenic differentiation.PMID 1656361Read ↗

Distinct effects of Rac1 on differentiation of primary avian myoblasts.Semantic proximity Read ↗

Conditional cell transformation by doxycycline-controlled expression of the ASV17 v-jun allele.Semantic proximity Read ↗

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.Semantic proximity Read ↗

Efficient induction of fibrosarcomas by v-jun requires mutations in the DNA binding region and the transactivation domain.Semantic proximity Read ↗

A temperature-conditional mutant of simian virus 40 large T antigen requires serum to inhibit myogenesis and does not induce DNA synthesis in myotubes.Semantic proximity Read ↗

Transcriptional down-regulation of myogenin expression is associated with v-ras-induced block of differentiation in unestablished quail muscle cells.Semantic proximity Read ↗

Characterization of heterokaryons between skeletal myoblasts and somatic cells formed by fusion with HVJ (Sendai virus); effects on myogenic differentiation.Semantic proximity Read ↗

Characterization of myogenin expression in myotubes derived from quail myoblasts transformed with a temperature sensitive mutant of Rous sarcoma virus.Semantic proximity Read ↗

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v-Myb DNA binding is required to block thrombocytic differentiation of Myb-Ets-transformed multipotent haematopoietic progenitors.Semantic proximity Read ↗

Transformation blocks differentiation-induced inhibition of serum response factor interactions with serum response elements.Semantic proximity Read ↗

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