Article
Genetic analysis of eight breast-ovarian cancer families with suspected BRCA1 mutations.
Journal of the National Cancer Institute. Monographs - 1 Jan 1995
Couch F J, Garber J, Kiousis S, Calzone K, Hauser E R, Merajver S D, Frank T S, Boehnke M, Chamberlain J S, Collins F S
Abstract excerpt
BRCA1 is a breast cancer-related tumor suppressor gene located on human chromosome 17q21. Inherited mutations in BRCA1 are thought to be responsible for approximately half of all inherited breast cancer and to confer increased risk for ovarian, colon, or prostate cancer. Studies of affected families and population-based studies have provided some information on the prevalence of BRCA1 mutations in Caucasian U.S....
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