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Article

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

21 Dec 1990

Abstract excerpt

Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Mapping the genes responsible for inherited breast cancer may also allow the identification of early lesions that are critical for the development of breast cancer in the general population. Chromosome 17q21 appears to be the locale of a gene for inherited...

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PMID: 2270482
DOI: 10.1126/science.2270482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21PMID 2270482Read ↗

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.Semantic proximity Read ↗

Linkage analysis with markers on 17q in 29 Swedish breast cancer families.Semantic proximity Read ↗

Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q.Semantic proximity Read ↗

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.Semantic proximity Read ↗

An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.Semantic proximity Read ↗

[Hereditary predisposition for cancer of the breast and the ovary].Semantic proximity Read ↗

A breast-ovarian cancer susceptibility gene maps to chromosome 17q21.Semantic proximity Read ↗

Genetic predisposition to breast cancer.Semantic proximity Read ↗

Familial breast cancer. Approaching the isolation of a susceptibility gene.Semantic proximity Read ↗

Breast cancer incidence, penetrance and survival in probable carriers of BRCA1 gene mutation in families linked to BRCA1 on chromosome 17q12-21.Semantic proximity Read ↗

Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers.Semantic proximity Read ↗

Characterization of 10 new polymorphic dinucleotide repeats and generation of a high-density microsatellite-based physical map of the BRCA1 region of chromosome 17q21.Semantic proximity Read ↗

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