Article
Linkage to BRCA2 region in hereditary male breast cancer.
Lancet (London, England) - 26 Aug 1995
Thorlacius S, Tryggvadottir L, Olafsdottir G H, Jonasson J G, Ogmundsdottir H M, Tulinius H, Eyfjord J E
Abstract excerpt
Breast cancer is rare in men, and family history of the disease is a risk factor. The recently discovered BRCA2 gene on chromosome 13q is thought to account for some families with increased risk of breast cancer, including male breast cancer. We describe a family with multiple cases of male breast cancer but, interestingly, no increase in female breast cancer. Linkage to the BRCA2 region is demonstrated and all...
Topics
- Aged
- Alleles
- Breast Neoplasms
- Breast Neoplasms, Male
- Chromosome Mapping
- Chromosomes, Human, Pair 13
- DNA, Neoplasm
- Female
- Genes, Tumor Suppressor
- Genes, p53
- Genetic Linkage