Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers.

doi:10.1007/BF01208638

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Article

Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers.

Journal of cancer research and clinical oncology - 1 Jan 1997

Chang-Claude J, Becher H, Eby N, Bastert G, Wahrendorf J, Hamann U

Abstract excerpt

Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index...

Topics

Adult
Age of Onset
Aged
Breast Neoplasms
Disease Susceptibility
Female
Genes, BRCA1
Genetic Linkage
Germany
Heterozygote
Humans
Middle Aged
Mutation
Proportional Hazards Models
Reproduction
Risk
Risk Factors
Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 9201250
DOI: 10.1007/BF01208638

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9201250-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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