Article
Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers.
Journal of cancer research and clinical oncology - 1 Jan 1997
Chang-Claude J, Becher H, Eby N, Bastert G, Wahrendorf J, Hamann U
Abstract excerpt
Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at onset of disease. We identified individuals showing a high probability of linkage to BRCA1 and...
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