Article
An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.
American journal of human genetics - 1 Jan 1995
Narod S A, Ford D, Devilee P, Barkardottir R B, Lynch H T, Smith S A, Ponder B A, Weber B L, Garber J E, Birch J M
Abstract excerpt
The breast-ovary cancer-family syndrome is a dominant predisposition to cancer of the breast and ovaries which has been mapped to chromosome region 17q12-q21. The majority, but not all, of breast-ovary cancer families show linkage to this susceptibility locus, designated BRCA1. We report here the results of a linkage analysis of 145 families with both breast and ovarian cancer. These families contain either a...
Topics
- Adult
- Age of Onset
- BRCA1 Protein
- Breast Neoplasms
- Breast Neoplasms, Male
- Chromosomes, Human, Pair 17
- Female
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Humans