Article
Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.
American journal of human genetics - 1 Jan 1995
Easton D F, Ford D, Bishop D T
Abstract excerpt
Dominant predisposition to early-onset breast cancer and/or ovarian cancer in many families is known to be the result of germ-line mutations in a gene on chromosome 17q, known as BRCA1. In this paper we use data from families with evidence of linkage to BRCA1 to estimate the age-specific risks of breast and ovarian cancer in BRCA1-mutation carriers and to examine the variation in risk between and within families....
Topics
- Adult
- Age of Onset
- Aged
- Alleles
- BRCA1 Protein
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Cohort Studies
- Female
- Genes, Dominant
- Humans
- Likelihood Functions