Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

doi:10.1016/s0140-6736(94)91578-4

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Article

Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

Lancet (London, England) - 19 Mar 1994

Ford D, Easton D F, Bishop D T, Narod S A, Goldgar D E

Abstract excerpt

Germline mutations in a gene on chromosome 17q known as BRCA1 are responsible for a large proportion of inherited predispositions to breast and ovarian cancer. In 33 families with evidence of linkage to BRCA1, we estimated the risks of breast and ovarian cancer from the occurrence of second cance...

Topics

Adult
Aged
Breast Neoplasms
Chromosomes, Human, 16-18
Female
Heterozygote
Humans
Male
Middle Aged
Mutation
Ovarian Neoplasms
Risk Factors

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