Familial breast cancer. Approaching the isolation of a susceptibility gene.

doi:10.1002/1097-0142(19940801)74:3+<1013::aid-cncr2820741507>3.0.co;2-#

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Article

Familial breast cancer. Approaching the isolation of a susceptibility gene.

Cancer - 1 Aug 1994

Weber B L, Abel K J, Brody L C, Flejter W L, Chandrasekharappa S C, Couch F J, Merajver S D, Collins F S

Abstract excerpt

Family history is recognized widely as a significant risk factor for the development of breast cancer. A gene (BRCA1), mutations in which confer susceptibility to early-onset breast and ovarian cancer, has been mapped to chromosome 17q12-21. An intensive search for this gene is currently underway...

Topics

Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 17
Female
Genes, Tumor Suppressor
Genetic Predisposition to Disease
Humans
Mutation

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