Article
Breast cancer incidence, penetrance and survival in probable carriers of BRCA1 gene mutation in families linked to BRCA1 on chromosome 17q12-21.
The British journal of surgery - 1 Oct 1994
Porter D E, Cohen B B, Wallace M R, Smyth E, Chetty U, Dixon J M, Steel C M, Carter D C
Abstract excerpt
Eight breast cancer pedigrees with a high probability of containing individuals with the BRCA1 gene mutation (odds 79.2-99.9 per cent) were identified through genetic linkage analysis using probes located within q12-22 on the long arm of chromosome 17. Some 102 female relatives were successfully...
Topics
- Adult
- Age Factors
- Aged
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Female
- Gene Frequency
- Genetic Carrier Screening
- Genetic Linkage
- Heterozygote
- Humans
- Incidence