Article
Increased p53 protein does not correlate to p53 gene mutations in microdissected human testicular germ cell tumors.
The Journal of urology - 1 Aug 1995
Schenkman N S, Sesterhenn I A, Washington L, Tong Y A, Weghorst C M, Buzard G S, Srivastava S, Moul J W
Abstract excerpt
PURPOSE: To determine if primary testicular germ cell tumors that overexpress p53 tumor suppressor gene protein have p53 gene mutations. MATERIALS AND METHODS: We examined 30 primary testicular tissues from 26 patients representing two groups. Group one consisted of eleven cases (6 nonseminomatou...
Topics
- Base Sequence
- Dissection
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Germinoma
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Testicular Neoplasms
- Tumor Suppressor Protein p53