Article
Increased p53 protein does not correlate to p53 gene mutations in microdissected human testicular germ cell tumors.
The Journal of urology - 1 Aug 1995
Schenkman N S, Sesterhenn I A, Washington L, Tong Y A, Weghorst C M, Buzard G S, Srivastava S, Moul J W
Abstract excerpt
PURPOSE: To determine if primary testicular germ cell tumors that overexpress p53 tumor suppressor gene protein have p53 gene mutations. MATERIALS AND METHODS: We examined 30 primary testicular tissues from 26 patients representing two groups. Group one consisted of eleven cases (6 nonseminomatous germ cell tumors and 5 seminomas) in which tissue samples for DNA analysis were microdissected from paraffin block...
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