Article
The p53 and mdm-2 genes in human testicular germ-cell tumors.
Molecular carcinogenesis - 1 Mar 1995
Riou G, Barrois M, Prost S, Terrier M J, Theodore C, Levine A J
Abstract excerpt
Mutations in the p53 gene are common in many cancers. They have been documented to occur in about 55% of all cancers of 51 different cell and tissue types. These mutations are accompanied by overexpression of the p53 protein in the nucleus of the cell, and this protein has lost its tumor suppressor function. In this study, 25 testicular germ-cell (TGC) tumors were tested for p53 mutations and the level of p53...
Topics
- Base Sequence
- Gene Amplification
- Genes, p53
- Germinoma
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational