Article
Altered patterns of MDM2 and TP53 expression in human bladder cancer.
Journal of the National Cancer Institute - 7 Sept 1994
Lianes P, Orlow I, Zhang Z F, Oliva M R, Sarkis A S, Reuter V E, Cordon-Cardo C
Abstract excerpt
BACKGROUND: The TP53 gene maps to the short arm of chromosome 17 (17p13.1) and encodes for a nuclear phosphoprotein of 53 kd (p53) involved in cell cycle control. The MDM2 gene is located on the long arm of chromosome 12 (12q13-14), and it encodes for a nuclear protein (Mdm2) of 90 kd of molecula...
Topics
- Aged
- Antibodies, Monoclonal
- Blotting, Southern
- Female
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genotype
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Phenotype
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2