17p13 (TP53) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas.

doi:10.1002/gcc.23271

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Article

17p13 (TP53) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas.

Genes, chromosomes & cancer - 1 Sept 2024

Kluth Martina, Hitzschke Melanie, Furlano Kira, Plage Henning, Hofbauer Sebastian, Weinberger Sarah, Ralla Bernhard, Fendler Annika, de Martino Michela, Roßner Florian, Schallenberg Simon, Elezkurtaj Sefer, Lennartz Maximilian, Marx Andreas H, Samtleben Henrik, Fisch Margit, Rink Michael, Slojewski Marcin, Kaczmarek Krystian, Ecke Thorsten, Koch Stefan, Adamini Nico, Weischenfeldt Joachim, Klatte Tobias, Minner Sarah, Simon Ronald, Sauter Guido, Schlomm Thorsten, Horst David, Zecha Henrik

Abstract excerpt

17p13 deletions including TP53 and other genes represent a common cause for reduced/lost p53 function in tumor cells. In this study, we analyzed the impact of 17p13 (TP53) deletions and p53 expression on tumor aggressiveness and patient prognosis in urothelial carcinoma. The 17p13 copy number status was analyzed by fluorescence in situ hybridization (FISH) on more than 2700 urothelial bladder carcinomas in a...

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PMID: 39324446
DOI: 10.1002/gcc.23271

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TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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