Article
Human papilloma virus DNA and p53 mutation analysis on bladder washes in relation to clinical outcome of bladder cancer.
European urology - 1 Aug 2007
Moonen Paula M J, Bakkers Judith M J E, Kiemeney Lambertus A L M, Schalken Jack A, Melchers Willem J G, Witjes J Alfred
Abstract excerpt
OBJECTIVES: High-risk human papilloma virus (HPV) types stimulate degradation and deactivation of protein associated with the p53 tumour suppressor gene via the ubiquitin-dependent pathway. For a long time, changes of the p53 tumour suppressor gene have been correlated with poor clinical outcome in patients with superficial bladder cancer. We aimed to study the association between presence of (high-risk) HPV DNA,...
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