Overexpression of MDM-2 mRNA and mutation of the p53 tumor suppressor gene in bladder carcinoma cell lines.

doi:10.1002/mc.2940130307

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Article

Overexpression of MDM-2 mRNA and mutation of the p53 tumor suppressor gene in bladder carcinoma cell lines.

Molecular carcinogenesis - 1 Jul 1995

Cheng Y T, Li Y L, Wu J D, Long S B, Tzai T S, Tzeng C C, Lai M D

Abstract excerpt

To investigate the importance of oncogenes and tumor suppressor genes in bladder carcinogenesis, we determined the status of the expression of the MDM-2 and p53 genes and genetic alterations in the p53 gene in five bladder carcinoma cell lines and one kidney urothelial carcinoma cell line. Overex...

Topics

Base Sequence
Carcinoma, Transitional Cell
Cell Line
DNA Primers
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Genes, ras
Humans
Kidney Neoplasms
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Polymorphism, Single-Stranded Conformational

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-mdm2

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 7619220
DOI: 10.1002/mc.2940130307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7619220-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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