Article
p53 gene mutations in gastric adenomas.
Virchows Archiv. B, Cell pathology including molecular pathology - 1 Jan 1993
Tohdo H, Yokozaki H, Haruma K, Kajiyama G, Tahara E
Abstract excerpt
p53 gene alterations in ten gastric adenomas and one carcinoma arising in an adenoma were analyzed by deoxynucleotide sequencing. Three (30%) of the ten gastric adenomas had p53 gene mutations, one adenoma showing a frameshift mutation and two others showing silent mutations. In addition, two missense mutations occurred in the carcinoma arising in an adenoma. Histologically, the adenomas containing silent...
Read the complete abstract on PubMedTopics
- Adenoma
- Base Sequence
- Codon
- Frameshift Mutation
- Genes, p53
- Humans
- Immunohistochemistry
