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Article

Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas.

Biochemical and biophysical research communications - 15 Aug 1994

Hayashi N, Sugimoto Y, Tsuchiya E, Ogawa M, Nakamura Y

Abstract excerpt

Cytogenetic abnormalities of chromosome 9p21-22 have been documented in human non-small cell lung carcinomas (NSCLC). Recently, a candidate tumor suppressor gene, MTS1/CDK4l, was identified in this chromosomal region and frequent homozygous deletions of this gene were found in cancer cell lines d...

Topics

Adenocarcinoma
Base Sequence
Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
Carrier Proteins
Chromosomes, Human, Pair 9
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases
DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Deletion

Humans

Lung Neoplasms

Molecular Sequence Data

Mutation

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins

RNA-Binding Proteins

Source

Identifiers

PMID: 8060323
DOI: 10.1006/bbrc.1994.2090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8060323-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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