Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas.

Biochemical and biophysical research communications - 15 Aug 1994

Hayashi N, Sugimoto Y, Tsuchiya E, Ogawa M, Nakamura Y

Abstract excerpt

Cytogenetic abnormalities of chromosome 9p21-22 have been documented in human non-small cell lung carcinomas (NSCLC). Recently, a candidate tumor suppressor gene, MTS1/CDK4l, was identified in this chromosomal region and frequent homozygous deletions of this gene were found in cancer cell lines derived from various types of tissues. We screened 64 primary NSCLCs, including 31 adenocarcinomas and 33 squamous cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Gene Deletion

Share to Lung Neoplasms

Share to Molecular Sequence Data

Share to Mutation

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 8060323
DOI: 10.1006/bbrc.1994.2090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas.PMID 8060323Read ↗

MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinomaSemantic proximity Read ↗

Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers.Semantic proximity Read ↗

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma.Semantic proximity Read ↗

Infrequent somatic mutation of the MTS1 gene in primary bladder carcinomas.Semantic proximity Read ↗

A cell cycle regulator potentially involved in genesis of many tumor types.Semantic proximity Read ↗

MTS1 gene mutations in archival oral squamous cell carcinomas.Semantic proximity Read ↗

Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias.Semantic proximity Read ↗

Analysis of MTS1/CDK4 in female breast carcinomas.Semantic proximity Read ↗

p53 mutations in primary human lung tumors and their metastases.Semantic proximity Read ↗

PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.Semantic proximity Read ↗

Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma.Semantic proximity Read ↗

[p16INK4/CDKN2 gene deletions and mutations in non-small cell lung cancers].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.