MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinoma

doi:10.1093/carcin/15.12.2683

Article

MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinoma

1 Jan 1994

Abstract excerpt

The MTS1/CDK4I gene encodes a 16 kDa cyclin kinase inhibitor and maps to chromosome 9p21. Previous studies have suggested the presence of a major tumour suppressor gene at this locus which may be inactivated in head and neck squamous cell carcinoma (HNSCC). To determine the status of this gene in human primary and metastatic HNSCC, we examined the locus and its transcript for abnormalities by polymerase chain...

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