Article
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma.
Nature genetics - 1 Sept 1994
Caldas C, Hahn S A, da Costa L T, Redston M S, Schutte M, Seymour A B, Weinstein C L, Hruban R H, Yeo C J, Kern S E
Abstract excerpt
The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4 complexes, and is deleted or mutated in a variety of tumour types. We found allelic deletions of 9p21-p22 in 85% of pancreatic adenocarcinomas. Analysis of MTS1 in pancreatic carcinomas (27 xenografts and 10 cell lines) showed homozygous deletions in 15 (41%) and sequence changes in 14 (38%). These included eight point mutations (four...
Topics
- Adenocarcinoma
- Base Sequence
- Carrier Proteins
- Chromosome Deletion
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p16
- Gene Deletion
- Genes, p53
- Humans
- Molecular Sequence Data