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Article

A cell cycle regulator potentially involved in genesis of many tumor types.

Science (New York, N.Y.) - 15 Apr 1994

Kamb A, Gruis N A, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian S V, Stockert E, Day R S, Johnson B E, Skolnick M H

Abstract excerpt

A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1), that encodes a previously identified inhibitor (p16) of cyclin-dependent kinase 4. MTS1 was homozygously deleted at high frequency in cell lines derived from...

Topics

Base Sequence
Carrier Proteins
Cell Cycle
Chromosomes, Human, Pair 9
Cosmids
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases
Exons
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Tumor Suppressor

Humans

Introns

Melanoma

Molecular Sequence Data

Mutation

Neoplasms

Protein Kinase Inhibitors

Source

Identifiers

PMID: 8153634
DOI: 10.1126/science.8153634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8153634-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A cell cycle regulator potentially involved in genesis of many tumor types.PMID 8153634Read ↗

[Discovery of a new gene frequently inactivated in human cancers: protein p16, a cell cycle regulator].Semantic proximity Read ↗

CDKN2A (p16INK4A) somatic and germline mutations.Semantic proximity Read ↗

Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.Semantic proximity Read ↗

Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval.Semantic proximity Read ↗

Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.Semantic proximity Read ↗

MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinomaSemantic proximity Read ↗

Polo-like kinase 1 is a potential therapeutic target in human melanoma.Semantic proximity Read ↗

Analysis of mutations and identification of several polymorphisms in the putative promoter region of the P34CDC2-related CDC2L1 gene located at 1P36 in melanoma cell lines and melanoma families.Semantic proximity Read ↗

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Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas.Semantic proximity Read ↗

Epigenetic silencing of novel tumor suppressors in malignant melanoma.Semantic proximity Read ↗

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