Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers.

doi:10.1002/ijc.2910630503

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Article

Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers.

International journal of cancer - 27 Nov 1995

Shimizu T, Sekiya T

Abstract excerpt

To elucidate the involvement of abnormalities of the MTS1/p16 and MTS2/p15 genes located at chromosomal region 9p21 in human lung cancers, we analyzed DNA from 30 primary lung cancers and detected loss of heterozygosity at the 9p21-p23 region in 15 tumors. Single-strand-conformation-polymorphism analysis of polymerase-chain-reaction products from the MTS1 and MTS2 genes and determination of the nucleotide...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Carrier Proteins
Cell Cycle Proteins
Chromosomes, Human, Pair 9
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
DNA, Neoplasm
DNA, Satellite
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Lung Neoplasms

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 7591275
DOI: 10.1002/ijc.2910630503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7591275-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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