Article
Infrequent somatic mutation of the MTS1 gene in primary bladder carcinomas.
Japanese journal of cancer research : Gann - 1 Mar 1995
Kai M, Arakawa H, Sugimoto Y, Murata Y, Ogawa M, Nakamura Y
Abstract excerpt
We examined a candidate tumor suppressor gene on chromosome 9p21, MTS1/CDK4I (multiple tumor suppressor 1/cyclin-dependent kinase 4 inhibitor), which has been found to be mutated frequently in cell lines derived from bladder carcinomas, for somatic mutations in 39 primary bladder cancers by means...
Topics
- Base Sequence
- Carrier Proteins
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p16
- Gene Deletion
- Humans
- Molecular Sequence Data
- Mutation
- Polymorphism, Single-Stranded Conformational
- Sequence Analysis, DNA
- Urinary Bladder Neoplasms