Article
Analysis of chromosome 22 markers in nine schizophrenia pedigrees.
American journal of medical genetics - 15 Mar 1994
Coon H, Holik J, Hoff M, Reimherr F, Wender P, Myles-Worsley M, Waldo M, Freedman R, Byerley W
Abstract excerpt
Previous results of a genome-wide survey for schizophrenia susceptibility genes in nine multiplex families indicated a possible region of linkage on chromosome 22. We therefore tested for linkage using ten highly polymorphic chromosome 22 DNA markers. Lod score analyses were suggestive of linkage...
Topics
- Adolescent
- Adult
- Alleles
- Cerebroside-Sulfatase
- Chromosomes, Human, Pair 22
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Lod Score
- Middle Aged
- Models, Genetic
- Pedigree
- Polymorphism, Restriction Fragment Length
- Repetitive Sequences, Nucleic Acid
- Schizophrenia
- Single-Blind Method