Article
Linkage studies on chromosome 22 in familial schizophrenia.
American journal of medical genetics - 24 Apr 1995
Vallada H P, Gill M, Sham P, Lim L C, Nanko S, Asherson P, Murray R M, McGuffin P, Owen M, Collier D
Abstract excerpt
As part of a systematic search for a major genetic locus for schizophrenia we have examined chromosome 22 using 14 highly polymorphic markers in 23 disease pedigrees. The markers were distributed at an average distance of 6.6 cM, covering 70-80% of the chromosome. We analyzed the data by the lod score method using five plausible genetic models ranging from dominant to recessive, after testing the power of our...
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