Article
Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5.
American journal of medical genetics - 21 Feb 1997
Chen A C, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P, Barnard E A, Petursson H, Gurling H M
Abstract excerpt
An abnormality in glutamatergic function has been hypothesized as being of etiological importance in schizophrenia. Twenty-three multiplex English and Icelandic schizophrenia families were genotyped with a polymorphic dinucleotide repeat sequence in the 3'-untranslated region of the glutamate/aspartate transporter gene called SLC1A5. Using the lod and a model-free method of linkage analysis (MFLINK), no evidence...
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