Article
Investigating the genetic basis for ankylosing spondylitis. Linkage studies with the major histocompatibility complex region.
Arthritis and rheumatism - 1 Aug 1994
Rubin L A, Amos C I, Wade J A, Martin J R, Bale S J, Little A H, Gladman D D, Bonney G E, Rubenstein J D, Siminovitch K A
Abstract excerpt
OBJECTIVE: To assess the hypothesis that B27 or a gene(s) in close proximity (e.g., within or near the major histocompatibility complex [MHC]) represents a disease-causing ankylosing spondylitis (AS) gene, and therefore contributes directly to the pathogenesis of this disorder. METHODS: MHC haplotypes were determined by both serologic and molecular analyses in 15 multiple-case AS families from Toronto and...
Topics
- Adolescent
- Adult
- Alleles
- Child
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- HLA-B27 Antigen
- Humans
- Major Histocompatibility Complex
- Male