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Article

Major histocompatibility genes and ankylosing spondylitis.

Best practice & research. Clinical rheumatology - 1 Jun 2006

Reveille John D

Abstract excerpt

The association of HLA-B27 with ankylosing spondylitis accounts for nearly 40% of the total disease risk. However, fewer than 5% of B27-positive individuals in the general population become affected. Genomewide scans suggest that other major histocompatibility complex genes further heighten this risk, although linkage disequilibrium with HLA-B27 has confounded their precise identification. Over 31 variants of...

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Identifiers

PMID: 16777585
DOI: 10.1016/j.berh.2006.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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