Breakthroughs in genetic studies of ankylosing spondylitis.

doi:10.1093/rheumatology/kem269

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Article

Breakthroughs in genetic studies of ankylosing spondylitis.

Rheumatology (Oxford, England) - 1 Feb 2008

Brown M A

Abstract excerpt

Ankylosing spondylitis (AS), the prototypic seronegative arthropathy, is known to be highly heritable, with >90% of the risk of developing the disease determined genetically. As with most common heritable diseases, progress in identifying the genes involved using family-based or candidate gene approaches has been slow. The recent development of the genome-wide association study approach has revolutionized genetic...

Topics

Aminopeptidases
Chromosome Mapping
Frameshift Mutation
Genetic Predisposition to Disease
Genome, Human
Humans
Major Histocompatibility Complex
Minor Histocompatibility Antigens
Polymerase Chain Reaction
Receptors, Interleukin
Spondylitis, Ankylosing

Source

Open in PubMed

Identifiers

PMID: 18037607
DOI: 10.1093/rheumatology/kem269

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