Article
The genetic background of ankylosing spondylitis.
Joint bone spine - 1 Dec 2009
Végvári Anikó, Szabó Zoltán, Szántó Sándor, Glant Tibor T, Mikecz Katalin, Szekanecz Zoltán
Abstract excerpt
It has long been known that the major histocompatibility complex (MHC) is essentially involved in genetic susceptibility to ankylosing spondylitis (AS). The HLA-B27 antigen has been accounted for 20 to 50% of the total genetic risk for this disease. However, susceptibility to AS cannot be fully explained by associations with the MHC. Recent studies including linkage analyses as well as candidate gene and, most...
Topics
- Animals
- Arthritis, Experimental
- Chromosome Mapping
- Disease Models, Animal
- Genetic Linkage
- Genetic Predisposition to Disease
- HLA-B27 Antigen
- Humans
- Mice
- Proteoglycans
- Spondylitis, Ankylosing