Article
Genetic studies in familial ankylosing spondylitis susceptibility.
Arthritis and rheumatism - 1 Jul 2004
Zhang Ge, Luo Jingchun, Bruckel Jane, Weisman Michael A, Schumacher H Ralph, Khan Muhammad A, Inman Robert D, Mahowald Maren, Maksymowych Walter P, Martin Tammy M, Yu David T Y, Stone Millicent, Rosenbaum James T, Newman Patricia, Lee Juwon, McClain Jo A, West O Clark, Jin Li, Reveille John D
Abstract excerpt
OBJECTIVE: To define the genetic basis of susceptibility to ankylosing spondylitis (AS), especially non-major histocompatibility complex (MHC) genes. METHODS: The study group comprised 244 affected sibling pairs from 180 pedigrees of primarily European ancestry. Sibling pairs were concordant for AS by the modified New York criteria and had available sacroiliac radiographs. The subjects were genotyped for 400...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 6
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Genotype
- HLA-DR Antigens
- HLA-DRB1 Chains