Article
An update on the contribution of the MHC to AS susceptibility.
Clinical rheumatology - 1 Jun 2014
Reveille John D
Abstract excerpt
The 40-year-old association of HLA-B27 with ankylosing spondylitis is one of the best examples of disease association with a hereditary marker. Genomewide association and family studies suggest that other important major histocompatibility complex (MHC) influences are operative in ankylosing spondylitis (AS) susceptibility. HLA-B27 positive hepatitis C individuals are immunologically more efficient in combating...
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