An update on the contribution of the MHC to AS susceptibility.

doi:10.1007/s10067-014-2662-7

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Article

An update on the contribution of the MHC to AS susceptibility.

Clinical rheumatology - 1 Jun 2014

Reveille John D

Abstract excerpt

The 40-year-old association of HLA-B27 with ankylosing spondylitis is one of the best examples of disease association with a hereditary marker. Genomewide association and family studies suggest that other important major histocompatibility complex (MHC) influences are operative in ankylosing spondylitis (AS) susceptibility. HLA-B27 positive hepatitis C individuals are immunologically more efficient in combating...

Topics

Adult
Aged
Alleles
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Geography
HLA-B27 Antigen
Humans
Major Histocompatibility Complex
Male
Middle Aged
Spondylarthritis
Spondylitis, Ankylosing
United States
Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 24838411
DOI: 10.1007/s10067-014-2662-7
PMCID: PMC4488903

Genes

MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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