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Article

Mutational analysis of secondary structure in the autoinhibitory and autophosphorylation domains of calmodulin kinase II.

The Journal of biological chemistry - 12 Aug 1994

Mukherji S, Brickey D A, Soderling T R

Abstract excerpt

A previous study has suggested that the autoinhibitory domain of Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) may contain an alpha-helical structure, which is important for the proper orientation of inhibitory residues to interact with the catalytic domain (Smith, M. K., Colbran, R. J., Brickey, D. A., and Soderling, T.R. (1992) J. Biol. Chem. 267, 1761-1768). The present study was designed to test...

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PMID: 8051174

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