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Article

Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.

The Journal of biological chemistry - 18 Nov 1994

Tokumitsu H, Brickey D A, Glod J, Hidaka H, Sikela J, Soderling T R

Abstract excerpt

This manuscript examines the mechanisms by which Ca2+/calmodulin-dependent protein kinase IV (CaM-kinase IV) is activated through the binding of Ca2+/CaM and by phosphorylation. Studies with the synthetic autoinhibitory domain peptides of CaM-kinase II indicate that CaM-kinase IV has a similarly located autoinhibitory domain, and this was confirmed since site-directed mutagenesis of this region (HMDT308 to DEDD...

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PMID: 7961813

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DEDD

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