Article
Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.
The Journal of biological chemistry - 18 Nov 1994
Tokumitsu H, Brickey D A, Glod J, Hidaka H, Sikela J, Soderling T R
Abstract excerpt
This manuscript examines the mechanisms by which Ca2+/calmodulin-dependent protein kinase IV (CaM-kinase IV) is activated through the binding of Ca2+/CaM and by phosphorylation. Studies with the synthetic autoinhibitory domain peptides of CaM-kinase II indicate that CaM-kinase IV has a similarly...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
- Calcium-Calmodulin-Dependent Protein Kinase Type 4
- Calcium-Calmodulin-Dependent Protein Kinases
- Cattle
- DNA Primers
- Enzyme Activation
- Humans
- Kinetics
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Serine-Threonine Kinases
- Rats