Intrasteric regulation of myosin light chain kinase.

doi:10.1074/jbc.270.28.16848

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Article

Intrasteric regulation of myosin light chain kinase.

The Journal of biological chemistry - 14 Jul 1995

Krueger J K, Padre R C, Stull J T

Abstract excerpt

Ca2+/calmodulin activates myosin light chain kinase by reversal of an autoinhibited state. The effects of substitution mutations on calmodulin activation properties implicate 4 of the 8 basic residues between the catalytic core and the calmodulin-binding domain in maintaining autoinhibition. Thes...

Topics

Amino Acid Sequence
Calmodulin
Kinetics
Molecular Sequence Data
Mutation
Myosin-Light-Chain Kinase
Structure-Activity Relationship

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