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Article

Calmodulin activation of target enzymes. Consequences of deletions in the central helix.

The Journal of biological chemistry - 5 Mar 1990

VanBerkum M F, George S E, Means A R

Abstract excerpt

The central helical region of calmodulin (CaM) includes amino acids 65-92 and serves to separate the two pairs of Ca2(+)-binding sites. This region may impart conformational flexibility and also interact with target proteins. The functional effects of deleting two, three, five, or eight amino acids from the central helix were monitored by examining the activation of phosphodiesterase, smooth muscle myosin light...

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PMID: 2154485

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