Calmodulin activation of target enzymes. Consequences of deletions in the central helix.

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Article

Calmodulin activation of target enzymes. Consequences of deletions in the central helix.

The Journal of biological chemistry - 5 Mar 1990

VanBerkum M F, George S E, Means A R

Abstract excerpt

The central helical region of calmodulin (CaM) includes amino acids 65-92 and serves to separate the two pairs of Ca2(+)-binding sites. This region may impart conformational flexibility and also interact with target proteins. The functional effects of deleting two, three, five, or eight amino aci...

Topics

Amino Acid Sequence
Base Sequence
Calcium-Calmodulin-Dependent Protein Kinases
Calmodulin
Chromosome Deletion
Cloning, Molecular
DNA Transposable Elements
Enzyme Activation
Kinetics
Molecular Sequence Data
Mutation
Myosin-Light-Chain Kinase
Phosphoric Diester Hydrolases
Plasmids
Protein Conformation
Protein Kinases
Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 2154485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2154485-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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