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Article

Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

The Journal of biological chemistry - 5 Sept 2003

Servitja Joan-Marc, Marinissen Maria Julia, Sodhi Akrit, Bustelo Xosé R, Gutkind J Silvio

Abstract excerpt

The proto-oncogene c-Src has been implicated in the development and progression of a number of human cancers including those of colon and breast. Accumulating evidence indicates that activated alleles of Src may induce cell transformation through Ras-ERK-dependent and -independent pathways. Here we show that Rac1 activity is strongly elevated in Src-transformed cells and that this small G protein is a critical...

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Identifiers

PMID: 12810717
DOI: 10.1074/jbc.M302960200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.PMID 12810717Read ↗

SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.Semantic proximity Read ↗

The guanine nucleotide exchange factor Tiam1: A Janus-faced molecule in cellular signalingSemantic proximity Read ↗

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.Semantic proximity Read ↗

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.Semantic proximity Read ↗

Mutation of Vav1 adaptor region reveals a new oncogenic activation.Semantic proximity Read ↗

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.Semantic proximity Read ↗

The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity.Semantic proximity Read ↗

Functions of the v-Src protein tyrosine kinase.Semantic proximity Read ↗

Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.Semantic proximity Read ↗

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components.Semantic proximity Read ↗

Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.Semantic proximity Read ↗

Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation.Semantic proximity Read ↗

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