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Article

Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation.

The Journal of biological chemistry - 10 Apr 2009

Hayes Matthew J, Moss Stephen E

Abstract excerpt

Cell transformation by v-Src involves rearrangement of the actin cytoskeleton, disassembly of focal adhesions, and the development of anchorage-independent growth. Here, we report that this is dependent on annexin 2, a v-Src substrate and calcium-dependent regulator of actin dynamics. Using a thermoactivatable mutant of v-Src, we show that at the permissive temperature, annexin 2 becomes phosphorylated and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Focal Adhesion Protein-Tyrosine Kinases

Share to Oncogene Protein pp60(v-src)

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Source

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Identifiers

PMID: 19193640
DOI: 10.1074/jbc.M807043200
PMCID: PMC2665074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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