Article
Transforming growth factor beta 1 suppresses transformation in hepatocytes by regulating alpha 1 beta 1 integrin expression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 1994
Serra R, Carbonetto S, Lord M, Isom H C
Abstract excerpt
We previously reported that (a) treatment of the ras-transformed hepatocyte cell line NR4 with transforming growth factor (TGF) beta 1 suppresses many characteristics associated with the transformed phenotype including altered morphology, actin cytoskeleton reorganization, and anchorage-independe...
Topics
- Animals
- Cell Adhesion
- Cell Line, Transformed
- Cell Membrane
- Cell Transformation, Neoplastic
- Collagen
- Cytoskeleton
- Gene Expression
- Genes, ras
- Integrin alpha1beta1
- Integrins
- Laminin
- Liver
- Phenotype
- RNA, Messenger
- Rats
- Transforming Growth Factor beta