Article
Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells.
Gastroenterology - 1 Aug 1998
Carloni V, Romanelli R G, Mercurio A M, Pinzani M, Laffi G, Cotrozzi G, Gentilini P
Abstract excerpt
BACKGROUND & AIMS: Hepatocellular carcinoma is a common complication in liver cirrhosis. The integrin alpha6 beta1, a receptor for the laminin family of extracellular matrix proteins, has been found to be overexpressed in hepatocarcinoma. In an effort to further characterize the involvement of al...
Topics
- Antigens, CD
- Carcinoma, Hepatocellular
- Cell Adhesion
- Cell Division
- Cell Movement
- Cell Transformation, Neoplastic
- Gene Deletion
- Humans
- Integrin alpha6beta1
- Integrin beta4
- Integrins
- Liver Neoplasms
- Neoplasm Invasiveness
- Peptide Fragments
- Phenotype
- Receptors, Laminin
- Transfection
- Tumor Cells, Cultured