Article
Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells.
Gastroenterology - 1 Aug 1998
Carloni V, Romanelli R G, Mercurio A M, Pinzani M, Laffi G, Cotrozzi G, Gentilini P
Abstract excerpt
BACKGROUND & AIMS: Hepatocellular carcinoma is a common complication in liver cirrhosis. The integrin alpha6 beta1, a receptor for the laminin family of extracellular matrix proteins, has been found to be overexpressed in hepatocarcinoma. In an effort to further characterize the involvement of alpha6 beta1-integrin in hepatocarcinoma progression and to study alpha6 beta1-mediated functions, a human...
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