Article
Differential modulation of basement membrane gene expression in human fibrosarcoma HT-1080 cells by transforming growth factor-beta 1. Enhanced type IV collagen and fibronectin gene expression correlates with altered culture phenotype of the cells.
Laboratory investigation; a journal of technical methods and pathology - 1 Jun 1991
Kähäri V M, Peltonen J, Chen Y Q, Uitto J
Abstract excerpt
The effects of transforming growth factor-beta 1 (TGF-beta 1) on the regulation of basement membrane gene expression were studied in human fibrosarcoma HT-1080 cell cultures. Treatment of cells with TGF-beta 1 resulted in a time- and dose-dependent enhancement of type IV collagen and fibronectin...
Topics
- Basement Membrane
- Collagen
- Dose-Response Relationship, Drug
- Extracellular Matrix
- Fibronectins
- Fibrosarcoma
- Gene Expression Regulation
- Humans
- Integrins
- Phenotype
- Protein Biosynthesis
- RNA, Messenger
- Time Factors
- Transforming Growth Factor beta