[Laminin and its alpha 6 integrin receptor in the regulation of human hepatocellular carcinoma cell phenotypes].

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Article

[Laminin and its alpha 6 integrin receptor in the regulation of human hepatocellular carcinoma cell phenotypes].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Jan 2003

Lu Tian-jing, Zhang Qing-yun, Zhou Rou-li

Abstract excerpt

OBJECTIVE: To study the role of integrin alpha 6 in cell attachment, spread, survival/proliferation and differentiation of human hepatocellular carcinoma (HCC) BEL-7402 cells on various substrates by monoclonal antibody against the extracellular domain of alpha 6 subunit (IA6ED McAb). METHODS: The effect of McAb on attachment and spread of BEL-7402 cells on LN or FN substrate was examined. MTT analysis was used...

Topics

Antibodies, Monoclonal
Carcinoma, Hepatocellular
Cell Adhesion
Humans
Integrin alpha6
Laminin
Liver Neoplasms
Phenotype
Receptors, Laminin
Tumor Cells, Cultured

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PMID: 12678983

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