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Article

Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness.

Journal of cell science - 15 Mar 2002

Gotzmann Josef, Huber Heidemarie, Thallinger Christiane, Wolschek Markus, Jansen Burkhard, Schulte-Hermann Rolf, Beug Hartmut, Mikulits Wolfgang

Abstract excerpt

In hepatocarcinogenesis, it is an open question whether transforming growth factor (TGF)-beta1 provides a tumor-suppressive or a tumor-promoting role. To address this question, we employed immortalized murine hepatocytes, which display a high degree of differentiation and, expectedly, arrest in the G1 phase under exposure to TGF-beta1. These hepatocytes maintain epithelial polarization upon expression of...

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Identifiers

PMID: 11884518
DOI: 10.1242/jcs.115.6.1189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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