Alpha 6 integrin is up-regulated in step increments accompanying neoplastic transformation and tumorigenic conversion of human fibroblasts.

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Article

Alpha 6 integrin is up-regulated in step increments accompanying neoplastic transformation and tumorigenic conversion of human fibroblasts.

Cancer research - 1 Jul 1993

Lin C S, Zhang K, Kramer R

Abstract excerpt

Integrins are a family of transmembrane glycoproteins that serve as cell-cell and cell-substratum adhesion molecules and help regulate cellular differentiation and proliferation. In malignant cells, which exhibit abnormal differentiation and growth properties, the expression of an altered integrin repertoire could therefore be expected. From a tumorigenic human fibrosarcoma cell line we isolated a unique...

Topics

Animals
Blotting, Northern
Cell Line
Cell Transformation, Neoplastic
DNA
DNA Probes
DNA, Neoplasm
Fibroblasts
Fibrosarcoma
Gene Expression
Humans
Integrins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA

RNA Splicing

RNA, Messenger

Rats

Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 7686445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7686445-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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