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Article

APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.

Neuroscience letters - 14 Mar 1994

Van Broeckhoven C, Backhovens H, Cruts M, Martin J J, Crook R, Houlden H, Hardy J

Abstract excerpt

A recent study has demonstrated an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (AD). Also, in late-onset AD families linked to chromosome 19, the onset age decreased when the number of APOE*4 alleles increased. A similar effect of the APOE*4 genotype was observed in early-onset AD families linked to mutations in the APP gene located on...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8047278
DOI: 10.1016/0304-3940(94)90385-9

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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