Article
APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.
Neuroscience letters - 14 Mar 1994
Van Broeckhoven C, Backhovens H, Cruts M, Martin J J, Crook R, Houlden H, Hardy J
Abstract excerpt
A recent study has demonstrated an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (AD). Also, in late-onset AD families linked to chromosome 19, the onset age decreased when the number of APOE*4 alleles increased. A similar effect of the APOE*4 genotype was observed in early-onset AD families linked to mutations in the APP gene located on...
Topics
- Age of Onset
- Aged
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Chromosomes, Human, Pair 14
- Genotype
- Humans
- Middle Aged