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Article

ApoE genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val-->Ile mutated families.

Neuroscience letters - 2 Jan 1995

Nacmias B, Latorraca S, Piersanti P, Forleo P, Piacentini S, Bracco L, Amaducci L, Sorbi S

Abstract excerpt

Recent studies have shown a genetic association of the apolipoprotein E (ApoE) epsilon 4 allele with late onset familial and sporadic Alzheimer's disease (AD). In this study we analysed the possible association of the genetic polymorphism of the ApoE gene with age of onset in Italian familial Alzheimer's disease (FAD) families including two early onset familial Alzheimer's (EOFAD) families with the APP717...

Topics

Age Factors
Age of Onset
Alzheimer Disease
Amyloid beta-Protein Precursor
Apolipoproteins E
Family
Genotype
Humans
Italy
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7746463
DOI: 10.1016/0304-3940(94)11100-w

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7746463-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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