ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families.

doi:10.1002/(sici)1096-8628(19980207)81:1<117::aid-ajmg19>3.0.co;2-m

Back to search

Article

ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families.

American journal of medical genetics - 7 Feb 1998

Houlden H, Crook R, Backhovens H, Prihar G, Baker M, Hutton M, Rossor M, Martin J J, Van Broeckhoven C, Hardy J

Abstract excerpt

The apolipoprotein E (ApoE) genotype is a significant risk factor and modulator of age of onset of Alzheimer's disease (AD). We analyzed the effect of the ApoE genotype in two distinct early-onset familial AD groups: families with a mutation in the presenilin-1 gene (PS-1) on chromosome 14, and f...

Topics

Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Genotype
Humans
Membrane Proteins
Mutation
Presenilin-1
Presenilin-2
Risk Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.