Article
ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families.
American journal of medical genetics - 7 Feb 1998
Houlden H, Crook R, Backhovens H, Prihar G, Baker M, Hutton M, Rossor M, Martin J J, Van Broeckhoven C, Hardy J
Abstract excerpt
The apolipoprotein E (ApoE) genotype is a significant risk factor and modulator of age of onset of Alzheimer's disease (AD). We analyzed the effect of the ApoE genotype in two distinct early-onset familial AD groups: families with a mutation in the presenilin-1 gene (PS-1) on chromosome 14, and families without a mutation detectable in the PS-1, presenilin-2 (PS-2), and the amyloid precursor protein (APP) gene...
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