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Article

Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease.

Annals of neurology - 1 Oct 1995

Levy-Lahad E, Lahad A, Wijsman E M, Bird T D, Schellenberg G D

Abstract excerpt

The effect of the apolipoprotein E (APOE) epsilon 4 allele on age of onset was analyzed in two groups of families with early-onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early-onset non-VG families showing evidence of linkage to chromosome 14. The epsilon 4 allele did not have a detectable effect on age of onset in either group. This finding...

Topics

Age of Onset
Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Genotype
Humans
Middle Aged
Time Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7574468
DOI: 10.1002/ana.410380420

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7574468-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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